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Anna Marie Lukco of Warren departed this life on Wednesday, October 3, with a peaceful look on her face as she chose to end her struggle with breast cancer. It should be noted that finally seeing the Browns win relieved her mind enough to allow her to move into the next realm. As the third of four children, she always felt her sister and brothers received more attention than her but the reality is that she was much kinder and less trouble than the others, subsequently requiring less direction. In her earlier years, Anna Marie enjoyed travel and adventure — spending a summer working at a Lodge in California, another period spent at a Dude Ranch near Yellowstone National Park and also living and working in Tampa, Florida. She was a familiar face to the many loyal customers of Waldenbooks for nearly 40 years — retiring as manager of the Eastwood Mall store. She was proud of the beautiful work she did around her home and the gardens on her property were stunning to behold.
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Ann-Marie Nagle

Author contributions: M. Annexin A1 AnxA1 is a candidate regulator of the epithelial- to mesenchymal EMT -like phenotypic switch, a pivotal event in breast cancer progression. We show here that AnxA1 expression is associated with a highly invasive basal-like breast cancer subtype both in a panel of human breast cancer cell lines as in breast cancer patients and that AnxA1 is functionally related to breast cancer progression. AnxA1 knockdown in invasive basal-like breast cancer cells reduced the number of spontaneous lung metastasis, whereas additional expression of AnxA1 enhanced metastatic spread. Using proteomic analysis we have previously identified AnxA1 and its family member AnxA2 as candidate regulators of oncogene-induced cell morphology switch 2.
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Sedgwick, Elizabeth C. Keck, of Pitcairn, Pa. Jane Nagle of Altoona.
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